MOTS-C

Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

Description: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by the mitochondrial genome rather than the cell nucleus. In laboratory settings, it is studied as a “mitokine” that facilitates mitochondrial-nuclear communication. Research primarily explores its role in activating the AMPK pathway, modulating the folate-methionine cycle, and its influence on metabolic homeostasis and cellular stress resistance in various animal and in vitro models.